Cu61Copper 61

Copper-61 is a radioisotope used in positron emission tomography (PET). It has a half-life of 3.33h. The use of this nuclide is currently low. However, its easy and especially inexpensive production in medical cyclotrons makes it an attractive radionuclide of copper.

To produce Copper 61,
we recommend this production route:

Recommended
Cyclone:
Cyclone^® KIUBE
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For small ⁶¹Cu production, the most cost effective solution is the irradiation of a liquid target at an energy around 16 MeV. Cyclone^® KIUBE can have different fixed exit energy with its Custom Energy feature allowing the highest purity.

Cyclone^® KIUBE can also be equipped with a degrador foil on the liquid target

More about Cyclone^® KIUBE

Target:
Nirta^® liquid target
The irradiation of inexpensive natural zinc via ⁶⁴Zn(p,α)⁶¹Cu nuclear reaction provides enough isotope for research applications.

More about Nirta^® liquid target

Chemistry:
Synthera^® Extension
The technique is capable of delivering several batches of purified ⁶¹Cu ([⁶¹Cu]Cl₂) with only 30 min of post-process after End-Of-Beam (EOB), while avoiding the pre- and post- irradiation technical difficulties arising from the use of conventional solid targets.

More about Synthera^® Extension

Scientific publications

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Cu61Copper 61

To produce Copper 61,we recommend this production route:

Cyclone:

Target:

Chemistry:

Scientific publications

CRITICAL POINTS FOR IMPROVEMENT OF PERFORMANCE IN A SUMMARY OF MODULE SYNTHERA 18FDG.

Automated syntheses of N-SUCCINIMIDYL 4-[18F]Fluorobenzoate ([18F]SFB) AND N-[2-(4-18F-Fluorobenzamido) Ethyl]maleimide([18F]FBEM) using a customised IBA synthetiser

Development of a Radiosynthesizer Module Designed to Produce Florbetapir F 18 (18F-AV-45) for Clinical Trials

Fully automated synthesis of apoptosis probe PET-18F-ML-10 with a multipurpose chemistry platform

Nucleophilic Labeling Reactions on Synthera: A Multipurpose Synthesis Platform

Automated radiosynthesis of [18F]FAZA with Synthera radiochemistry box

Radiopharmacy Unit. Experience with the Synthera® chemistry module:

Automated synthesis of [18F] fluoroacetate using a compact FDG synthesizer

Automated production of [18F] 2-fluoroethyl azide and a thymidine analogue using the Synthera module

A simplified protocol for the automated production of succinimidyl 4‐[18F] fluorobenzoate on an IBA Synthera module

A rapid and simple automated synthesis of 18F-MISO

Nucleophilic labeling reactions on a multipurpose synthesis platform.

Automated synthesis of therapeutic activities of 177Lu and 131I radiopharmaceuticals and 68Ga PET agents in a hospital radiopharmacy.

Optimisation of the automated synthesis of 18F-FMISO using the Synthera[registered] Platform

Nucleophilic labeling reactions on a multipurpose synthesis platform.

Optimization of [18F]-FDG production with terminal sterilization by autoclave.

Synthesis of stereochemically pure 18F-cis-4-fluoro-L-proline on an automated synthesis module.

Routine production in a GMP environment of multiple 18F-radiopharmaceuticals on a disposable-based fully automated platform

Fully automated synthesis of 18F-FET using the Synthera[registered] Platform

Automated synthesis of N-succinimidyl 3-[211At]astatobenzoate (SAB) for antibodies radiolabelling.

Automated [68Ga]DOTA-NOC Production Using a Commercial Synthesizer

Automated synthesis of 18F-labeled ligands for pre- and postsynaptic PET imaging of the dopaminergic system using IBA Synthera modules

Fully automated production of [18F]fluoroacetate on IBA Synthera platform

Improved synthesis and purification of meta-[18F]fluorobenzylguanidine (mFBG) for clinical use

Synthesis of 18F-L-FDOPA via Nucleophilic Pathway on IBA's Synthera®

Simplified Automation of the GMP production of 68Ga-labelled peptides

Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera® and Synthera® Extension modules

Combining commercial production of multi-products in a GMP environment with Clinical & R&D activities

Synthesis and purification of hexadecyl-4-[18F]fluorobenzoate using the cassettebased Synthera® module for labeling exosomes and macromolecules

Optimization of final product DMAE content is 18F-Fluorocholine process using double IBA Synthera® process

Automated radiosynthesis of the 18F-fluoropropylsulfonyl derivative of TAK875, a FFA1-binding PET radiotracer for β-cell mass imaging.

GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects

Routine Production of [18F]PSMA-1007 and First Clinical Experience in Staging of Prostate Cancer Patients

Automated Purification of Radiometals Produced by Liquid Targets

A high molar activity 18F-labeled TAK-875 derivative for PET imaging of pancreatic β- cells

Synthera Users Official Declaration

A simplified radiosynthesis of [18F]MK‐6240 for tau PET imaging

Combining multi-product commercial production in a GMP environment with Clinical & R&D activities

Production of 124I and 64Cu on an 18/9 MeV cyclotron as a starting material for radiopharmaceuticals preparation

Evaluation of the radionuclidic purity of 123I and 131I samples

The new bern cyclotron laboratory for radioisotope production and research

Gamma-ray spectrometric characterization of waste activated target components in a pet cyclotron

Performance of IBA new Conical shaped Niobium [18O] water Targets

Performance of IBA new Conical shaped Niobium [18O] water Targets

18F- saturation yield in Large Volume cylindrical IBA target

Development of a Krypton Target for Cyclone-30 at KFSH&RC

Temperature Model Verification and Beam Characterization on a Solid Target System

Reducing Metal Contamination in Cu-64 Production

Fully Automated Production of Zr-89 Using IBA Nirta and Pinctada Systems

Development of [NH3] Ammonia target for Cyclone-30 at KFSH&RC

STABLE AND CONSISTENT PRODUCTION OF 13 N-A MMONIA IN A N IOBIUM TARGET

Low current performance of the Bern medical cyclotron down to the pA range

Cyclotron production of Ga‐68 for human use from liquid targets: From theory to practice

Development of a nickel plated aluminum krypton-81m target system

GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects

Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets

Fast and cost-effective cyclotron production of 61Cu using a natZn liquid target: an opportunity for radiopharmaceutical production and R&D

Modernization program of Cyclone®18/9 at ASAN Medical Center, Seoul

The Cyclone® 70 installed at Zevacor Molecular (Indianapolis)

Characterization of the secondary neutron field generated by a compact PET cyclotron with MCNP6 and experimental measurements

A New Powerful Compact Cyclotron

Optimized non-conventional radioisotopes production with industrial mid-energy cyclotron

Analysis of Radioisotopic Metal Impurities Generated in (O-18) H2O during F-18 Production with Cyclotron

High yield automated production of the PET radioisotope 86Y using a biomedical cyclotron

Experimental and Monte Carlo characterization of radionuclidic impurities originated from proton irradiation of [18O]H2O in a modern medical cyclotron

First experience on producing gallium-68 with liquid target at HUS Medical Imaging Center using a Cyclone KIUBE 180 cyclotron

Simulation by FLUKA of the self-activation of a cyclotron IBA Cyclone® 18

The methodology of characterization of neutron leakage field from PET production cyclotron for experimental purposes

A new compact high power e-beam accelerator for radioisotopes production: a first evaluation

EXPERIENCES WITH THE CYCLONE 3 OXYGEN 15 GENERATOR

Development of 111In‐labeled porphyrins for SPECT imaging

Feasibility Study on the Production of Technetium-99m on an IBA 18/9 Cyclotron Using a COSTIS Solid Target System

Developments toward the Implementation of 44Sc Production at a Medical Cyclotron

Modernization program of Cyclone®18 at CRC, ULg

To produce Copper 61,
we recommend this production route:

Automated syntheses of N-SUCCINIMIDYL 4-[¹⁸F]Fluorobenzoate ([¹⁸F]SFB) AND N-[2-(4-¹⁸F-Fluorobenzamido) Ethyl]maleimide([^18F]FBEM) using a customised IBA synthetiser

Development of a Radiosynthesizer Module Designed to Produce Florbetapir F 18 (¹⁸F-AV-45) for Clinical Trials

Fully automated synthesis of apoptosis probe PET-¹⁸F-ML-10 with a multipurpose chemistry platform

Automated radiosynthesis of [¹⁸F]FAZA with Synthera radiochemistry box

Radiopharmacy Unit. Experience with the Synthera^® chemistry module:

Automated synthesis of therapeutic activities of 177Lu and 131I radiopharmaceuticals and ⁶⁸Ga PET agents in a hospital radiopharmacy.

Optimisation of the automated synthesis of 18F-FMISO using the Synthera^[registered] Platform

Synthesis of stereochemically pure ¹⁸F-cis-4-fluoro-L-proline on an automated synthesis module.

Fully automated synthesis of 18F-FET using the Synthera^[registered] Platform

Automated synthesis of N-succinimidyl 3-[²¹¹At]astatobenzoate (SAB) for antibodies radiolabelling.

Automated [⁶⁸Ga]DOTA-NOC Production Using a Commercial Synthesizer

Automated synthesis of ¹⁸F-labeled ligands for pre- and postsynaptic PET imaging of the dopaminergic system using IBA Synthera modules

Fully automated production of [¹⁸F]fluoroacetate on IBA Synthera platform

Synthesis of 18F-L-FDOPA via Nucleophilic Pathway on IBA's Synthera^®

Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera^® and Synthera^® Extension modules

Synthesis and purification of hexadecyl-4-[18F]fluorobenzoate using the cassettebased Synthera^® module for labeling exosomes and macromolecules

Optimization of final product DMAE content is 18F-Fluorocholine process using double IBA Synthera^® process

Production of ¹²⁴I and ⁶⁴Cu on an 18/9 MeV cyclotron as a starting material for radiopharmaceuticals preparation

Performance of IBA new Conical shaped Niobium [¹⁸O] water Targets

Performance of IBA new Conical shaped Niobium [¹⁸O] water Targets

Development of [NH₃] Ammonia target for Cyclone-30 at KFSH&RC

Modernization program of Cyclone^®18/9 at ASAN Medical Center, Seoul

The Cyclone^® 70 installed at Zevacor Molecular (Indianapolis)

Simulation by FLUKA of the self-activation of a cyclotron IBA Cyclone^® 18

Modernization program of Cyclone^®18 at CRC, ULg