To produce 68Ga on a cyclotron, the positively charged ions must reach the target at 13 MeV. With its unique Custom Energy feature, the Cyclone® KIUBE has different exit energy enabling you to reach the highest amount of 68Ga production at high purity.
For smaller productions, the Cyclone® KIUBE can also be equipped with a degrador foil to reach the target at 13 MeV.
Nirta® Liquid target
The irradiation of enriched zinc solution takes place in the Nirta® 68Ga Conical liquid target. The production of 68Ga using a liquid target is a simple & cost- effective GMP solution similar to the 18F process.
Synthera® Extension, Synrhera® +
The solution recovered from the target is purified on a Synthera® Extension with a two-step purification process (solid phase extraction) leading to [68Ga ]GaCl3. The labelling can then be performed using a cold kit or the Synthera®+ .
The Synthera®+ system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.
Process under Patent EP15170854