Thinking about starting a Cardiac PET MPI Program?
Thinking about starting a Cardiac PET MPI Program?
Webinar ASNC on-demand, sponsored by IBA
Prof. Panithaya Chareonthaitawee & Prof. Nils Johnson
Prof Dr Chareonthaitawee and Prof Dr Johnson recently shared invaluable insights on launching a successful cardiac PET MPI program and advanced methods for measuring absolute blood flow with short-lived isotopes to enhance diagnosis and patient care.
ASNC 2025 Highlight
Rethinking Coronary Flow Reserve: A Step Toward Personalized Risk Prediction
Prof Dr Simone Brandão, MD, MSc, PhD
"At the ASNC 2025 Plenary Session in Orlando, groundbreaking preliminary results from the REFINE PET registry were presented by Lee Joseph (first author) and Marcelo Di Carli (senior author), from the Brigham and Women’s Hospital CV Imaging group.
This work is defining normal reference values for myocardial flow reserve (MFR) across age and sex.
Until now, clinicians have relied on a fixed threshold of 2.0, applied uniformly. However, data from REFINE PET clearly demonstrate that:
- MFR varies across the lifespan.
- Men and women differ in expected values.
- A “one-size-fits-all” cutoff may misclassify cardiovascular risk.
Why does this matter?
- MFR quantifies the vasodilatory capacity of the coronary microcirculation.
- In patients without obstructive CAD, reduced MFR reflects microvascular dysfunction.
- A large body of evidence confirms its strong association with adverse outcomes, including mortality.
By introducing age- and sex-adjusted percentiles, this study enables REFINED risk stratification, showing improved reclassification compared with traditional fixed thresholds. Ultimately, this approach moves us closer to personalized cardiovascular prediction and management.
We look forward to the full publication of this work, which promises to reshape how MFR is applied in clinical cardiology and nuclear imaging worldwide."
Reference:
Personalized Risk Prediction with Age- and Sex-Specific Myocardial Flow Reserve Percentiles
Joseph, Lee et al. Journal of Nuclear Cardiology, Volume 50, 102378