Skip to main content

How to produce <strong>Gallium 68</strong>

Cyclotron
Target
Chemistry
Optimized production route (Process under Patent EP15170854)
Cyclone® KIUBE

Cyclone® KIUBE

<p><span>To produce </span><sup>68</sup><span>Ga on a cyclotron, the positively charged ions must reach the target at 13 MeV. With its unique Custom Energy feature, the Cyclone<sup>®</sup> KIUBE has different exit energy enabling you to reach the highest amount of </span><sup>68</sup><span>Ga production at high purity.&nbsp;</span></p> <p><span>For smaller productions, the Cyclone<sup>®</sup> KIUBE can also be equipped with a degrador foil to reach the target at 13 MeV.&nbsp;</span></p> More about Cyclone® KIUBE
See more
Nirta® Liquid Target

Nirta® Liquid Target

<p><span>The irradiation of enriched zinc solution takes place in the Nirta<sup>®&nbsp;&nbsp;</sup></span><sup>68</sup><span>Ga&nbsp;Conical liquid target. The production of </span><sup>68</sup><span>Ga&nbsp;using a liquid target is a simple &amp; cost- effective GMP solution similar to the </span><sup>18</sup><span>F&nbsp;process.</span></p> More about Nirta®  liquid target
See more
Synthera® Extension
Synthera® +

Synthera® Extension
Synthera® +

<p><span>The solution recovered from the target is purified on a Synthera<sup>®</sup> Extension with a two-step purification process (solid phase extraction) leading to [</span><sup>68</sup><span>Ga&nbsp;]GaCl<sub>3</sub>. The labelling can then be performed using a cold kit or the &nbsp;Synthera<sup>®</sup>+ . The Synthera<sup>®</sup>+ system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></p> More about Synthera® Extension & Synthera® +
See more
Alternative
Cyclone® KIUBE

Cyclone® KIUBE

<p><span>To produce </span><sup>68</sup><span>Ga on a cyclotron, the positively charged ions must reach the target at 13 <span>MeV</span>. With its unique Custom Energy feature, the Cyclone<sup>®</sup> <span>KIUBE</span> has different exit energy <span>enabling</span> you to reach the highest amount of </span><sup>68</sup><span>Ga production at high purity.&nbsp;</span></p> <p><span>For smaller productions, the Cyclone<sup>®</sup> <span>KIUBE</span> can <span>also</span> be equipped with a <span>degrador</span> foil to reach the target at 13 <span>MeV</span>.&nbsp;</span></p> More about Cyclone® KIUBE
See more
Solid Target

Solid Target

<p><sup>68</sup><span>Ga&nbsp;can also be obtained using a solid target. The process is more complicated.&nbsp;</span></p> <p><span>Target support only is provided by IBA</span></p>
See more
Dissolution module & Purification

Dissolution module & Purification

<p><span>The irradiated target material can be purified and used for further labelling.</span></p> <p><br /> <span>Chemistry support only provided by IBA</span></p>
See more
Alternative
68Ge from generator

68Ge from generator

<p><span><span><span>The </span></span></span><sup>68</sup><span><span><span>Ge&nbsp;produced by Cyclone<sup>®</sup>&nbsp;30 &nbsp;is used for the manufacturing of &nbsp;the &nbsp;generator </span></span></span><sup>68</sup><span><span><span>Ge/</span></span></span><sup>68</sup><span><span><span>Ga. The </span></span></span><sup>68</sup><span><span><span>Ge&nbsp;is a &nbsp;long half-life &nbsp;isotope (270,95 days), the generator can be shipped around the world.</span></span></span></p> More about Cyclone® 30
See more
Synthera® Extension
Synthera® +

Synthera® Extension
Synthera® +

<p><span><span><span>The </span></span></span><sup>68</sup><span><span><span>Ga from the generator is <strong>eluted with the help of the Synthera</strong><sup>®</sup><strong> Extension</strong>. The labelling can then be performed using a cold kit or the &nbsp;Synthera<sup>®</sup>+ . The Synthera<sup>®</sup> system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></span></span></p> More about Synthera® Extension & Synthera® +
See more

Ask your <strong>Expert!</strong>

The team of experts can help you manage the selection, installation, process and qualification of all equipment needed for you radiopharmaceutical production.