Carbon 11

Carbon-11 is commonly used in positron emission tomography (PET). It has a short half life of 20.4 minutes.
This isotope is mostly used in-house worldwide for brain imaging studies.

How to produce Carbon 11

Optimized production route

Cyclone® KIUBE

To produce 11C, the protons need to reach the target at 16- 18MeV. The Cyclone® KIUBE is thus ideal for 11C production. This cyclotron has 8 exit ports, giving you the flexibility to produce a wide range of radioisotopes.  More about Cyclone® KIUBE

Nirta® Gas target

Proton bombardment of nitrogen gas causes the 14N(p,α)11C nuclear reaction. 2 Gas Target available;  -  [11C]CO2 bombardment in the presence of oxygen produces [11C]carbon dioxide - [11C]CH4  bombardment in the presence of hydrogen produces[11C]methane. More about Nirta® target

Carbon 11 chemistry module

Diverse solutions can be used for the synthesis of a wide range of 11C labelled molecules: PIB, Acetate, Choline, Methionine, Raclopride, … More about carbon 11 chemistry

Alternative

Cyclone® IKON

It is also possible to use the Cyclone® IKON for 11C production using an energy of 18 MeV More about Cyclone® IKON

Nirta® Gas target

Proton bombardment of nitrogen gas causes the 14N(p,α)11C nuclear reaction. 2 Gas Target available; - [11C]CO2 bombardment in the presence of oxygen produces [11C]carbon dioxide - [11C]CH4  bombardment in the presence hydrogen produces[11C]methane. More about Nirta® target

Carbon 11 chemistry module

Diverse solutions can be used for the synthesis of a wide range of 11C labelled molecules: PIB, Acetate, Choline, Methionine, Raclopride, … More about carbon 11 chemistry

Resources

Scientific publications

Simulation by FLUKA of the self-activation of a cyclotron IBA Cyclone® 18

Simone Manenti^1,2, Francesco Broggi², Riccardo Calandrino³, Flavia Groppi^1,2 1 Department of Physics, Università degli Studi di Milano, Milano, Italy 2 INFN/Milano, Milano, Italy 3 Medical Physics, San Raffaele Scientific Institute, Milano, Italy

Modernization program of Cyclone®18/9 at ASAN Medical Center, Seoul

ASAN Medical Center, Seoul, South Korea

Combining multi-product commercial production in a GMP environment with Clinical & R&D activities

Gameiro¹, Cristiana; Bormans², Guy; Abrunhosa³, Antero; ⁴Luurtsema, G. and Elsinga⁴,Philip

1 IBA-Ion Beam applications SA/BE; 2 PET Center, University of Leuven/BE; 3 ICNAS, University of Coimbra/PT; 4 Medical Imaging Centre, University of Groningen/NL.

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