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The Cyclotron was placed into its final position at Guangdong SinoTau Molecular Imaging Technology Co., Ltd. The new radiophamacy is equipped with cutting edge technology; the Cyclone® KIUBE Custom Energy and Synthera®+ synthesizers to ensure a reliable production of F-18 and Ga-68 tracers as well as Z-89 and Cu-64 on solid target. Congratulations to Zhaobing, Jenny, Hubert and all the team involved!

IBA invites you to attend a free webinar presented by 3 leading personalities in Nuclear Medicine, Radiation Oncology and Medical Physics: Dr Jeremie Calais, PD Dr. med. Stefan Körber and Dr. Kai Schubert.  In this webinar, the speakers will highlight the synergy between highly sensitive imaging, the definition of an intermediate stage between non-disseminated tumor and widespread metastatic disease (oligometastatic state) and high-precision radiation therapy (Stereotactic Body Radiation Therapy - SBRT) focused to treat the oligometastatic lesions. When? April 26th, 5-6 pm CET  REGISTER What will you learn from the webinar ?  •      Impact of PSMA PET on management of patients with oligo metastatic prostate cancer By Dr. Jeremie Calais, Director of the Clinical Research Program of the Nuclear Medicine and Theranostics Division at UCLA.  Dr Calais will cover the concept of oligometastatic disease in prostate cancer patients and the impact of PSMA PET imaging on the therapy management of those patients.   •    The Role of SBRT in the treatment of oligometastatic prostate cancer: Why & how SBRT for these patients By PD Dr. med. Stefan Körber,  First Senior Medical Doctor at Clinic for Radiation Oncology and Radiation Therapy at University Clinic of Heidelberg, Germany Dr. Körber will describe how the oligometastatic status of prostate cancer patients is defined on the basis of PSMA PET/CT and which strategies and modalities are applied for SBRT treatment of these patients    •    Quality assurance for SBRT treatments By Dr. Kai Schubert, Medical Physicist at Clinic for Radiation Oncology and Radiation Therapy at University Clinic of Heidelberg, Germany. The extremely high precision of SBRT requires an extensive program of Quality Assurance, both for the treatment machines as for the patient-specific treatment plans. Dr. Schubert will explain current strategies and future developments in this field.  REGISTER  

RESILIENT PERFORMANCE ACROSS BUSINESS LINES GOOD ORDER INTAKE AND RECORD BACKLOG POSITIVE REBIT AND BOTTOM LINE STRONG BALANCE SHEET WITH EUR 65 MILLION NET CASH AT YEAR END Louvain-la-Neuve, Belgium, 25 March 2021 - IBA (Ion Beam Applications SA), the world’s leading provider of proton therapy solutions for the treatment of cancer, today announces its consolidated annual results for the 2020 financial year.   Olivier Legrain, Chief Executive Officer of IBA commented: “I am very proud of IBA’s good performance and resilience in what has been a challenging year globally. Our long-term strategy aims to build upon our solid business foundation to create sustainable growth and profitability, delivering the very best offering and services to our customers, whilst being a responsible corporate citizen. Our roadmap to achieve this across all four of our business lines is clear: capitalize on our market leading position globally, invest for strategic impact and deliver operational execution. “A key strategic growth market for us is Asia, particularly China, and we were pleased to sign two significant proton therapy deals in the region in the second half of 2020, as well as a strategic partnership with CGNNT in China. We also delivered strong sales in this region for our Industrial, RadioPharma and Dosimetry businesses. This momentum has continued in 2021, with IBA being selected for the supply of a new Proteus®PLUS solution in China. “Our pipeline continues to be encouraging and overall, order intake across all business units remains buoyant. This, coupled with our growing recurring revenues in Services and Dosimetry, provides us with confidence for the future. I am grateful for the incredible work of the IBA team over the past year, as well as the continued support of our customers. With a healthy balance sheet and the long-term potential for market development across all four of our businesses, we enter 2021 in a confident position.” Financial summary ▪ Total order intake of EUR 112 million for Proton Therapy and Other Accelerators (excluding CGNNT contract) and EUR 54 million for Dosimetry ▪ Total 2020 Group revenues of EUR 312 million, up 10.4%, strongly boosted by the strategic licensing deal with CGN Nuclear Technology Application Co Ltd (CGNNT) ▪ Strong growth in Proton Therapy Services for the third consecutive year, up 7.2% from 2019 ▪ Equipment and Services backlog conversion delayed due to effects of pandemic but remains at all time high of EUR 1.1 billion ▪ Significant increase to full year REBIT, with a profit of EUR 40.4 million (2019: EUR 0.1 million) ▪ Total Group net profit of EUR 31.9 million (2019: EUR 7.6 million) ▪ Very strong balance sheet with EUR 151.3 million gross cash (2019: EUR 46 million) and EUR 65.2 million net cash position (2019: net debt of EUR -21.3 million), with all bank covenants met at year-end ▪ Total direct COVID-19 impact for 2020 estimated to be around EUR 15 million ▪ The Board of Directors will recommend to the annual general assembly the distribution of a total dividend of EUR 0.2 per share, in line with the transition to a new dividend policy Business summary ▪ Proteus®PLUS* licensing deal with Chinese partner CGNNT worth minimum of EUR 100 million announced during the year, with EUR 63.5 million revenues recognized in 2020 ▪ Four-room contract for a Proteus®PLUS Proton Therapy Solution announced in Chengdu, Sichuan Province, China ▪ Contract signed with the National Cancer Center (NCC) Korea for a Proteus®ONE* solution, following a competitive tender process. NCC is already an IBA customer, having previously purchased a three-room Proteus®PLUS solution ▪ Strong order intake for Other Accelerators with 17 systems sold, of which 12 were signed in the second half ▪ Resilient performance of Dosimetry with a strong order intake in the year to date, up 10% from 2019 ▪ Strong cost control measures still in place, partially offsetting COVID-19 related impact, whilst allowing for strategic investments in R&D ▪ Board strengthened with appointment of Ms. Christine Dubus and Dr Richard Hausmann as Non-Executive Directors Post-period highlights ▪ In January, IBA was selected for the supply of a multi-room Proteus®PLUS solution in China, with contract negotiations ongoing ▪ In February, IBA received the third payment related to the CGNNT contract, for EUR 20 million, bringing total cash received to date on this contract to EUR 70 million ▪ In March, IBA received the first down payment on the NCC Korea contract signed in December 2020.

Did you miss the webinar about 68Ga-PSMA : from production to clinical applications? Watch the recordings   Thank you Prof. Francisco Alves and Dr. Jeremie Calais for your instructive presentations about Ga-PSMA: from production to applications. Here is a couple of questions that were answered during the Q&A:  How do you see the use of 66Ga for imaging? Could you clarify and give more information about; the minimal isotope composition of your enriched zinc-68, the impact in the impurity profile and the highest shelf-life that you can have?   Did you look at any correlation between PSA doubling time and velocity with the detection rate?  What’s the differences between FPSMA and Ga-PSMA?   For further information, you can read the published paper below.