O15Oxygen 15

Oxygen-15 is an isotope used in positron emission tomography (PET). It has a half-life of about 2 minutes. There are several uses for this isotope: ¹⁵O for oxygen consumption measurements, [¹⁵O]CO for lung perfusion and mainly as ¹⁵O-water used for measuring regional cerebral blood and for myocardial perfusion imaging.

To produce Oxygen 15,
we recommend this production route:

Recommended
Cyclone:
Cyclone^® KIUBE
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To produce ¹⁵O a cyclotron using positively charged ions, the optimal energy to reach the target is 13 MeV. The Cyclone^® KIUBE is equipped with a degrador foil on the ¹⁵O target to reach the 13 MeV.

More about Cyclone^® KIUBE

Target:
Nirta^® Gas target
Nirta^® Gas target is an irradiation system for the production of [¹⁵O]O₂ or [¹⁵O]CO. The irradiation of low volume of enriched ¹⁵N with proton produces the ¹⁵O isotope.

More about Nirta^® gas target

Chemistry:
¹⁵O water module
<sup>15</sup>O water module is a fully automated module that employs effective flow chemistry to produce high yield of [¹⁵O]H₂O in batch mode

More about ¹⁵O water module

Scientific publications

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O15Oxygen 15

To produce Oxygen 15,we recommend this production route:

Cyclone:

Target:

Chemistry:

Scientific publications

CRITICAL POINTS FOR IMPROVEMENT OF PERFORMANCE IN A SUMMARY OF MODULE SYNTHERA 18FDG.

Automated syntheses of N-SUCCINIMIDYL 4-[18F]Fluorobenzoate ([18F]SFB) AND N-[2-(4-18F-Fluorobenzamido) Ethyl]maleimide([18F]FBEM) using a customised IBA synthetiser

Development of a Radiosynthesizer Module Designed to Produce Florbetapir F 18 (18F-AV-45) for Clinical Trials

Fully automated synthesis of apoptosis probe PET-18F-ML-10 with a multipurpose chemistry platform

Nucleophilic Labeling Reactions on Synthera: A Multipurpose Synthesis Platform

Automated radiosynthesis of [18F]FAZA with Synthera radiochemistry box

Radiopharmacy Unit. Experience with the Synthera® chemistry module:

Automated synthesis of [18F] fluoroacetate using a compact FDG synthesizer

Automated production of [18F] 2-fluoroethyl azide and a thymidine analogue using the Synthera module

A simplified protocol for the automated production of succinimidyl 4‐[18F] fluorobenzoate on an IBA Synthera module

A rapid and simple automated synthesis of 18F-MISO

Nucleophilic labeling reactions on a multipurpose synthesis platform.

Automated synthesis of therapeutic activities of 177Lu and 131I radiopharmaceuticals and 68Ga PET agents in a hospital radiopharmacy.

Optimisation of the automated synthesis of 18F-FMISO using the Synthera[registered] Platform

Nucleophilic labeling reactions on a multipurpose synthesis platform.

Optimization of [18F]-FDG production with terminal sterilization by autoclave.

Synthesis of stereochemically pure 18F-cis-4-fluoro-L-proline on an automated synthesis module.

Routine production in a GMP environment of multiple 18F-radiopharmaceuticals on a disposable-based fully automated platform

Fully automated synthesis of 18F-FET using the Synthera[registered] Platform

Automated synthesis of N-succinimidyl 3-[211At]astatobenzoate (SAB) for antibodies radiolabelling.

Automated [68Ga]DOTA-NOC Production Using a Commercial Synthesizer

Automated synthesis of 18F-labeled ligands for pre- and postsynaptic PET imaging of the dopaminergic system using IBA Synthera modules

Fully automated production of [18F]fluoroacetate on IBA Synthera platform

Improved synthesis and purification of meta-[18F]fluorobenzylguanidine (mFBG) for clinical use

Synthesis of 18F-L-FDOPA via Nucleophilic Pathway on IBA's Synthera®

Simplified Automation of the GMP production of 68Ga-labelled peptides

Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera® and Synthera® Extension modules

Combining commercial production of multi-products in a GMP environment with Clinical & R&D activities

Synthesis and purification of hexadecyl-4-[18F]fluorobenzoate using the cassettebased Synthera® module for labeling exosomes and macromolecules

Optimization of final product DMAE content is 18F-Fluorocholine process using double IBA Synthera® process

Automated radiosynthesis of the 18F-fluoropropylsulfonyl derivative of TAK875, a FFA1-binding PET radiotracer for β-cell mass imaging.

GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects

Routine Production of [18F]PSMA-1007 and First Clinical Experience in Staging of Prostate Cancer Patients

Automated Purification of Radiometals Produced by Liquid Targets

A high molar activity 18F-labeled TAK-875 derivative for PET imaging of pancreatic β- cells

Synthera Users Official Declaration

A simplified radiosynthesis of [18F]MK‐6240 for tau PET imaging

Combining multi-product commercial production in a GMP environment with Clinical & R&D activities

Production of 124I and 64Cu on an 18/9 MeV cyclotron as a starting material for radiopharmaceuticals preparation

Evaluation of the radionuclidic purity of 123I and 131I samples

The new bern cyclotron laboratory for radioisotope production and research

Gamma-ray spectrometric characterization of waste activated target components in a pet cyclotron

Performance of IBA new Conical shaped Niobium [18O] water Targets

Performance of IBA new Conical shaped Niobium [18O] water Targets

18F- saturation yield in Large Volume cylindrical IBA target

Development of a Krypton Target for Cyclone-30 at KFSH&RC

Temperature Model Verification and Beam Characterization on a Solid Target System

Reducing Metal Contamination in Cu-64 Production

Fully Automated Production of Zr-89 Using IBA Nirta and Pinctada Systems

Development of [NH3] Ammonia target for Cyclone-30 at KFSH&RC

STABLE AND CONSISTENT PRODUCTION OF 13 N-A MMONIA IN A N IOBIUM TARGET

Low current performance of the Bern medical cyclotron down to the pA range

Cyclotron production of Ga‐68 for human use from liquid targets: From theory to practice

Development of a nickel plated aluminum krypton-81m target system

GMP Production of Gallium-68 from a Cyclotron Using Liquid Targets: Regulatory Aspects

Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets

Fast and cost-effective cyclotron production of 61Cu using a natZn liquid target: an opportunity for radiopharmaceutical production and R&D

Modernization program of Cyclone®18/9 at ASAN Medical Center, Seoul

The Cyclone® 70 installed at Zevacor Molecular (Indianapolis)

Characterization of the secondary neutron field generated by a compact PET cyclotron with MCNP6 and experimental measurements

A New Powerful Compact Cyclotron

Optimized non-conventional radioisotopes production with industrial mid-energy cyclotron

Analysis of Radioisotopic Metal Impurities Generated in (O-18) H2O during F-18 Production with Cyclotron

High yield automated production of the PET radioisotope 86Y using a biomedical cyclotron

Experimental and Monte Carlo characterization of radionuclidic impurities originated from proton irradiation of [18O]H2O in a modern medical cyclotron

First experience on producing gallium-68 with liquid target at HUS Medical Imaging Center using a Cyclone KIUBE 180 cyclotron

Simulation by FLUKA of the self-activation of a cyclotron IBA Cyclone® 18

The methodology of characterization of neutron leakage field from PET production cyclotron for experimental purposes

A new compact high power e-beam accelerator for radioisotopes production: a first evaluation

EXPERIENCES WITH THE CYCLONE 3 OXYGEN 15 GENERATOR

Development of 111In‐labeled porphyrins for SPECT imaging

Feasibility Study on the Production of Technetium-99m on an IBA 18/9 Cyclotron Using a COSTIS Solid Target System

Developments toward the Implementation of 44Sc Production at a Medical Cyclotron

Modernization program of Cyclone®18 at CRC, ULg

To produce Oxygen 15,
we recommend this production route:

Automated syntheses of N-SUCCINIMIDYL 4-[¹⁸F]Fluorobenzoate ([¹⁸F]SFB) AND N-[2-(4-¹⁸F-Fluorobenzamido) Ethyl]maleimide([^18F]FBEM) using a customised IBA synthetiser

Development of a Radiosynthesizer Module Designed to Produce Florbetapir F 18 (¹⁸F-AV-45) for Clinical Trials

Fully automated synthesis of apoptosis probe PET-¹⁸F-ML-10 with a multipurpose chemistry platform

Automated radiosynthesis of [¹⁸F]FAZA with Synthera radiochemistry box

Radiopharmacy Unit. Experience with the Synthera^® chemistry module:

Automated synthesis of therapeutic activities of 177Lu and 131I radiopharmaceuticals and ⁶⁸Ga PET agents in a hospital radiopharmacy.

Optimisation of the automated synthesis of 18F-FMISO using the Synthera^[registered] Platform

Synthesis of stereochemically pure ¹⁸F-cis-4-fluoro-L-proline on an automated synthesis module.

Fully automated synthesis of 18F-FET using the Synthera^[registered] Platform

Automated synthesis of N-succinimidyl 3-[²¹¹At]astatobenzoate (SAB) for antibodies radiolabelling.

Automated [⁶⁸Ga]DOTA-NOC Production Using a Commercial Synthesizer

Automated synthesis of ¹⁸F-labeled ligands for pre- and postsynaptic PET imaging of the dopaminergic system using IBA Synthera modules

Fully automated production of [¹⁸F]fluoroacetate on IBA Synthera platform

Synthesis of 18F-L-FDOPA via Nucleophilic Pathway on IBA's Synthera^®

Fully automated synthesis of 68Ga-labelled peptides using the IBA Synthera^® and Synthera^® Extension modules

Synthesis and purification of hexadecyl-4-[18F]fluorobenzoate using the cassettebased Synthera^® module for labeling exosomes and macromolecules

Optimization of final product DMAE content is 18F-Fluorocholine process using double IBA Synthera^® process

Production of ¹²⁴I and ⁶⁴Cu on an 18/9 MeV cyclotron as a starting material for radiopharmaceuticals preparation

Performance of IBA new Conical shaped Niobium [¹⁸O] water Targets

Performance of IBA new Conical shaped Niobium [¹⁸O] water Targets

Development of [NH₃] Ammonia target for Cyclone-30 at KFSH&RC

Modernization program of Cyclone^®18/9 at ASAN Medical Center, Seoul

The Cyclone^® 70 installed at Zevacor Molecular (Indianapolis)

Simulation by FLUKA of the self-activation of a cyclotron IBA Cyclone^® 18

Modernization program of Cyclone^®18 at CRC, ULg