How do see the role of PET-CT in the workflow of the patient going through immunotherapy?
There are several different applications for PET in immunotherapy. Here are the major ones:
- to stratify/select patients (before the start of therapy)
- to evaluate therapy response (before and after therapy, observing the change in signal that would indicate activation/proliferation of T cells)
- to evaluate off target toxicity (during treatment, observing the signal in off target (non-tumor) tissue)
Can you comment on the impact of the non-label Ab activity on the imaging?
In the Phase I study, with increasing protein dose (addition of non-labeled Ab), we found that higher amounts resulted in prolonged blood circulation, although signals in lymphoid tissues (spleen, lymph nodes, bone marrow) remained strong.
Details of the first six patients in the dose-escalation study are available in the recent publication by Pandit-Taskar et al., J. Nucl. Med, online first. doi:10.2967/jnumed.119.229781
- Dr Wu