
How to produce <strong>Gallium 68</strong>
Cyclotron
Target
Chemistry
Optimized production route (Process under Patent EP15170854)
Cyclone® KIUBE
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Cyclone® KIUBE
<p><span>To produce </span><sup>68</sup><span>Ga on a cyclotron, the positively charged ions must reach the target at 13 MeV. With its unique Custom Energy feature, the Cyclone<sup>®</sup> KIUBE has different exit energy enabling you to reach the highest amount of </span><sup>68</sup><span>Ga production at high purity. </span></p> <p><span>For smaller productions, the Cyclone<sup>®</sup> KIUBE can also be equipped with a degrador foil to reach the target at 13 MeV. </span></p> More about Cyclone® KIUBE
Nirta® Liquid Target
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Nirta® Liquid Target
<p><span>The irradiation of enriched zinc solution takes place in the Nirta<sup>® </sup></span><sup>68</sup><span>Ga Conical liquid target. The production of </span><sup>68</sup><span>Ga using a liquid target is a simple & cost- effective GMP solution similar to the </span><sup>18</sup><span>F process.</span></p> More about Nirta® liquid target
Synthera® Extension
Synthera® +
Synthera® Extension
<p><span>The solution recovered from the target is purified on a Synthera<sup>®</sup> Extension with a two-step purification process (solid phase extraction) leading to [</span><sup>68</sup><span>Ga ]GaCl<sub>3</sub>. The labelling can then be performed using a cold kit or the Synthera<sup>®</sup>+ . The Synthera<sup>®</sup>+ system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></p>
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Synthera® +
Synthera® Extension
Synthera® +
<p><span>The solution recovered from the target is purified on a Synthera<sup>®</sup> Extension with a two-step purification process (solid phase extraction) leading to [</span><sup>68</sup><span>Ga ]GaCl<sub>3</sub>. The labelling can then be performed using a cold kit or the Synthera<sup>®</sup>+ . The Synthera<sup>®</sup>+ system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></p>
More about Synthera® Extension & Synthera® +
Alternative
Cyclone® KIUBE
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Cyclone® KIUBE
<p><span>To produce </span><sup>68</sup><span>Ga on a cyclotron, the positively charged ions must reach the target at 13 <span>MeV</span>. With its unique Custom Energy feature, the Cyclone<sup>®</sup> <span>KIUBE</span> has different exit energy <span>enabling</span> you to reach the highest amount of </span><sup>68</sup><span>Ga production at high purity. </span></p> <p><span>For smaller productions, the Cyclone<sup>®</sup> <span>KIUBE</span> can <span>also</span> be equipped with a <span>degrador</span> foil to reach the target at 13 <span>MeV</span>. </span></p> More about Cyclone® KIUBE
Solid Target
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Solid Target
<p><sup>68</sup><span>Ga can also be obtained using a solid target. The process is more complicated. </span></p> <p><span>Target support only is provided by IBA</span></p>
Dissolution module & Purification
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Dissolution module & Purification
<p><span>The irradiated target material can be purified and used for further labelling.</span></p> <p><br /> <span>Chemistry support only provided by IBA</span></p>
Cyclone® IKON
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Cyclone® IKON
<p>It is also possible to use the Cyclone<sup><sup>®</sup> </sup>IKON for <sup>68</sup>Ga production using an energy of 13 MeV</p> More about Cyclone® IKON
Solid Target
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Solid Target
<p><sup>68</sup><span>Ga can also be obtained using a solid target. The process is more complicated. </span></p> <p><span>Target support only is provided by <span>IBA</span></span></p>
Dissolution module & Purification
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Dissolution module & Purification
<p><span>The irradiated target material can be purified and used for further labelling.</span></p> <p><br /> <span>Chemistry support only provided by <span>IBA</span></span></p>
Alternative
68Ge from generator
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68Ge from generator
<p><span><span><span>The </span></span></span><sup>68</sup><span><span><span>Ge produced by Cyclone<sup>®</sup> 30 is used for the manufacturing of the generator </span></span></span><sup>68</sup><span><span><span>Ge/</span></span></span><sup>68</sup><span><span><span>Ga. The </span></span></span><sup>68</sup><span><span><span>Ge is a long half-life isotope (270,95 days), the generator can be shipped around the world.</span></span></span></p> More about Cyclone® 30
Synthera® Extension
Synthera® +
Synthera® Extension
<p><span><span><span>The </span></span></span><sup>68</sup><span><span><span>Ga from the generator is <strong>eluted with the help of the Synthera</strong><sup>®</sup><strong> Extension</strong>. The labelling can then be performed using a cold kit or the Synthera<sup>®</sup>+ . The Synthera<sup>®</sup> system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></span></span></p>
More about Synthera® Extension & Synthera® +
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Synthera® +
Synthera® Extension
Synthera® +
<p><span><span><span>The </span></span></span><sup>68</sup><span><span><span>Ga from the generator is <strong>eluted with the help of the Synthera</strong><sup>®</sup><strong> Extension</strong>. The labelling can then be performed using a cold kit or the Synthera<sup>®</sup>+ . The Synthera<sup>®</sup> system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.</span></span></span></p>
More about Synthera® Extension & Synthera® +
Resources
Scientific publications
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